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Risek: When gastric ulcer is suspected, the possibility of malignancy should be excluded as treatment may alleviate symptoms and delay diagnosis. Prior to initiation of dual or triple therapy, the physician should consider the patient with known hypersensitivity reactions to penicillin, macrolides and other antibiotics.
Hepatic Impairment: Consideration should be given to reducing the dose of omeprazole in patients with impaired hepatic function as bioavailability and t½ can increase.
Risek Insta: Symptomatic response to therapy with omeprazole does not preclude the presence of gastric malignancy.
Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole.
Omeprazole powder for oral suspension contains sodium in the form of sodium bicarbonate. This should be taken into consideration for patients on a sodium-restricted diet.
Sodium bicarbonate should be used with caution in patients with Bartter's syndrome, hypokalemia, respiratory alkalosis and problems with acid-base balance.
Long-term administration of bicarbonate with calcium or milk can cause milk-alkali syndrome.
Use in Pregnancy: There are no adequate or well-controlled studies in pregnant women. Omeprazole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Use in Lactation: Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from omeprazole, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Risek: It is not known whether omeprazole is excreted in human milk
Risek Insta: Omeprazole is excreted in human milk. In addition, sodium bicarbonate should be used with caution in nursing mothers.
